Medicine Journeys: How Do Cannabis and Psilocybin Interact?

Olivia Love
5 min readNov 21, 2023

If you are a psychonaut, cannabis enthusiast, or novice interested in working with natural allies, but unsure of compounding effects, caution, intentionality, practice, and guidance can help you find the combination that best supports you.

Photo by author, at Grand Central Station in NYC

The interaction between cannabis and psilocybin (the psychoactive compound in magic mushrooms) is complex and can vary greatly depending on the person, the context, the setting, and the medicines and dosages being worked with. While many people report finding it useful to work with psilocybin mushrooms and cannabis in a complementary manner, it is important to be aware of potential risks and effects when doing so.

Some possible effects of adding cannabis use to a psilocybin journey include the following:

  • Amplification of Effects: Some people report that using cannabis as an adjunct to a psilocybin journey can intensify the psychedelic experience. Adding cannabis can heighten visual and auditory senses and amplify alterations in perception and mood. Many people find working with cannabis to be helpful particularly in the take off and landing phases of the mushroom journey; while cannabis can support a journey, it also adds its own quality to the journey. Remember that cannabis is well-known to be a trickster medicine; it is helpful to ensure you feel comfortable with the particular medicines you are taking individually before layering different substances that have compounding effects.
  • Increased Anxiety: Adding cannabis , especially at high dosages, to a psilocybin journey may increase the risk of anxiety, paranoia, or a bad trip. It is important to become adept at working with psilocybin and cannabis as medicines individually and becoming familiar with their effects before layering the two substances together. As cannabis can sometimes lead to heightened anxiety, it can exacerbate anxiety and feelings of distortion during a psilocybin journey. This is also why facilitators cannot emphasize enough the importance of set and setting — your mindset going into a journey and the environment and context you are journeying within.
  • Unpredictable Reactions: Combining the potent medicines of psilocybin mushrooms and cannabis can lead to unpredictable reactions, as both substances affect the brain…

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